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DLGAP2

Protein-coding gene in the species Homo sapiens

Wikipedia contributorsAdapted for Fathomly · View authors

1 min read
Source updated September 7, 2026

Disks large-associated protein 2 is a protein that in humans is encoded by the DLGAP2 gene.

01Function

The product of this gene is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells. These kinases are a family of signaling molecules expressed at various submembrane domains and contain the PDZ, SH3 and the guanylate kinase domains. This protein may play a role in the molecular organization of synapses and in neuronal cell signaling. Alternatively spliced transcript variants encoding different isoforms have been identified, but their full-length nature is not known.

02Interactions

DLGAP2 has been shown to interact with DLG4, the canonical synapse marker protein, which in turn binds to N-Methyl-d-aspartate (NMDA) receptors and Shaker-type K+ channels.

03Clinical significance

As with many other synaptic genes, including its binding partner SHANK2, DLGAP2 has been shown to be associated with autism.

Watch videos about DLGAP2Explainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “DLGAP2”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Ideogram human chromosome 8.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain

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