DHX29
Protein-coding gene in the species Homo sapiens
01Function
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.
02Interactions
DHX29 has been shown to interact with the eukaryotic small ribosomal subunit (40S) and eIF3.
Sources and credits
This article is adapted from the Wikipedia article “DHX29”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 5.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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