Cubilin
Mammalian protein found in humans
Cubilin is a protein that in humans is encoded by the CUBN gene. It is present upon the luminal surface of enterocytes of the ileum where it facilitates absorption of vitamin B12 by acting as a receptor for IF-cobalamin (intrinsic factor - vitamin B12) complexes, enabling endocytosis of complexes by means of amnionless (AMN).
01Biochemistry
Cubilinis essentially only present in the small intestine and kidneys.
A complex of amnionless and cubilin forms the cubam receptor.
02Clinical significance
Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
Cubilin is a potential diagnostic and prognostic cancer biomarker for kidney cancer. Based on patient survival data, high levels of cubilin in tumor cells is a favourable prognostic biomarker in renal cell carcinoma.
Sources and credits
This article is adapted from the Wikipedia article “Cubilin”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 10.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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