Complement component 5
Protein found in humans
Complement component 5 is a protein that in humans is encoded by the C5 gene.
Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b:
- C5a plays an important role in chemotaxis.
- C5b forms the first part of the complement membrane attack complex.
Deficiency is thought to cause Leiner's disease.
01Function
Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a C5-convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
02Clinical significance
Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
03Therapeutic applications
The drug eculizumab (trade name Soliris) prevents cleavage of C5 into C5a and C5b.
Sources and credits
This article is adapted from the Wikipedia article “Complement component 5”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- C5.png by Pietro Roversi, Public domain
- Formowanie MAC-en.svg by Formowanie_MAC.svg derivative work: Beao, CC BY-SA 3.0
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