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CPSF6

Protein-coding gene in humans

Wikipedia contributorsAdapted for Fathomly · View authors

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Source updated September 13, 2026

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Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.

01Function

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

02Interactions

CPSF6 has been shown to interact with WWP1 and PLSCR1.

CPSF6 plays an important role in the nuclear import and integration of HIV-1 capsids.

Watch videos about CPSF6Explainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “CPSF6”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

CFIm25-CFIm68 complex, Homo sapiens - Cleavage and polyadenylation specificity factor subunit 6 (2) 3P5T.png by Unknown author, CC0

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