CEBPD
Protein-coding gene in the species Homo sapiens
01Function
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.
02Functions
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.
Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.
03Interactions
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.
Sources and credits
This article is adapted from the Wikipedia article “CEBPD”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 8.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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