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Integrin alpha 5

Protein

Wikipedia contributorsAdapted for Fathomly · View authors
1 min read
Source updated September 1, 2026
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Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

01Interactions

ITGA5 has been shown to interact with GIPC1.

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Sources and credits

This article is adapted from the Wikipedia article “Integrin alpha 5”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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