CD120
Protein family
| tumor necrosis factor receptor superfamily, member 1B | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TNFRSF1B | ||||||
| Alt. symbols | CD120a, TNFR2 | ||||||
| NCBI gene | 7133 | ||||||
| HGNC | 11917 | ||||||
| OMIM | 191191 | ||||||
| RefSeq | NM_001066 | ||||||
| UniProt | P20333 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p36.22 | ||||||
| |||||||
CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).
01Receptor subtypes
There are two variants of the receptor, each encoded by a separate gene:
- CD120a - TNFR1 - TNFR superfamily member 1A
- CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior, and is involved in neurotoxic processes. Elevated levels of TNFR1 has been found in severe mental disorders.
Sources and credits
This article is adapted from the Wikipedia article “CD120”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- TNF signaling.jpg by Original uploaded by Subclavian (Transfered by Vojtech.dostal), Public domain
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