BRD7
Protein-coding gene in the species Homo sapiens
01Interactions
02Azoospermia
BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced. Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.
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- Ideogram human chromosome 16.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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