Arogenic acid
Chemical compound
Arogenic acid is an intermediate in the biosynthesis of phenylalanine and tyrosine. At physiological pH it exists as its conjugate base arogenate as the acid form is unstable.
01Metabolism
Arogenate is synthesized from prephenate by transamination. This reaction can be catalyzed by several enzymes, including aromatic-amino-acid transaminase, aspartate, prephenate aminotransferase and glutamate, prephenate aminotransferase:
- prephenate + amino acid → arogenate + keto acid
The amino acid in this case can be either aspartate or glutamate, which turn into oxaloacetate and 2-oxoglutarate, respectively.
Arogenate is then turned into either phenylalanine or tyrosine. When prephenate dehydratase or arogenate dehydratase act upon arogenate, phenylalanine is produced:
- arogenate → phenylalanine + H2O + CO2
When arogenate dehydrogenase, arogenate dehydrogenase (NAD(P)+) or arogenate dehydrogenase (NADP+) acts upon arogenate, tyrosine is produced:
L-arogenate + NAD+ CO2 CO2 L-tyrosine + NADHSources and credits
This article is adapted from the Wikipedia article “Arogenic acid”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- L-Arogenate structure.svg by Fliffey, CC BY-SA 4.0
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