ARF4
Protein-coding gene in the species Homo sapiens
01Gene
ADP-ribosylation factor 4 (ARF4) is a member of the human ARF gene family.
The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1 and ARF3), class II (ARF4, this gene and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. The ARF4 is the most divergent member of the human ARFs. Conflicting Map positions at 3p14 or 3p21 have been reported for this gene.
02Function
These genes encode small Guanine-nucleotide binding proteins (G proteins) that play a role in vesicular trafficking and as activators of phospholipase D.
03Clinical significance
ARF4 stimulates the ADP-ribosyltransferase activity of cholera toxin.
04Interactions
ARF4 has been shown to interact with Epidermal growth factor receptor and with RVxP motifs.
Sources and credits
This article is adapted from the Wikipedia article “ARF4”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
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