APOBEC3D
Protein-coding gene in the species Homo sapiens
Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.
01Function
APOBEC3D is one of the human APOBEC3 enzymes involved in restriction of HIV-1. HIV-1 Vif counteracts APOBEC3D by recruiting ubiquitin-ligase machinery that leads to its polyubiquitination and proteasomal degradation in virus-producing cells.
Sources and credits
This article is adapted from the Wikipedia article “APOBEC3D”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 22.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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