API5
Protein-coding gene in the species Homo sapiens
The human gene API5 encodes the protein Apoptosis inhibitor 5.
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibits the function for protein-protein interaction
Diseases associated with API5 include colon adenocarcinoma and cervical cancer.
API5 functions in nuclear export of mRNA.
Sources and credits
This article is adapted from the Wikipedia article “API5”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 11.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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