AP1S1
Protein-coding gene in the species Homo sapiens
01Function
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported.
A mutation in the AP1S1 causes the rare familial MEDNIK syndrome described in 2008.
02Interactions
Sources and credits
This article is adapted from the Wikipedia article “AP1S1”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- AP-1 complex subunit sigma-1A within the AP1 clathrin adaptor core 1W63.png by Heldwein EE, Macia E, Wang J, Yin HL, Kirchhausen T, CC0
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