AMELY
Protein-coding gene in humans
Amelogenin, Y isoform is a protein that in humans is encoded by the AMELY gene. AMELY is located on the Y chromosome and encodes a form of amelogenin. Amelogenin is an extracellular matrix protein involved in biomineralization during tooth enamel development.
01Clinical significance
Mutations in the related AMELX gene on the X chromosome cause X-linked amelogenesis imperfecta.
The presence or lack of the Y isoform of Amelogenin in fossilized enamel can be used to determine the sex of ancient hominids.
Sources and credits
This article is adapted from the Wikipedia article “AMELY”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome Y.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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