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AH-494

Chemical compound

Wikipedia contributorsAdapted for Fathomly · View authors
1 min read
Source updated September 17, 2026
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AH-494 is a potent and selective, water-soluble full agonist at the 5-HT7 serotonin receptor of the imidazolylindole family. It is a close derivative of the known chemical probe 5-Carboxamidotryptamine, as well as of the more lipophilic imidazolylindoles: AGH-107 and AGH-192. It has been shown to exhibit favorable ADMET profile in in-vitro assays.

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This article is adapted from the Wikipedia article “AH-494”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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Related topics

Substituted tryptamine

Substituted tryptamines, or simply tryptamines, also known as serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring system, joined to an amino (NH2) group via an ethyl (−CH2-CH2−) sidechain.

Imidazolylindole

Imidazolylindoles are a group of cyclized tryptamines in which the amine has been cyclized into an imidazole ring. They include AGH-107, AGH-192, AGH-194 and AH-494.

AGH-107

AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5-HT7 serotonin receptor of the imidazolylindole family. AGH-107 is one of the few examples of low-basicity aminergic receptor agonists, which may underlie its high selectivity over the related central nervous system targets.