ABCC12
Protein-coding gene in the species Homo sapiens
Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.
01Function
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. Loss of function is implicated in hereditary cholestasis.
Sources and credits
This article is adapted from the Wikipedia article “ABCC12”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 16.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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