Reference articles on history, science, culture and more
Surprise meSurprise meSubscribe
Encyclopedia

1ZP2MA

Pharmaceutical compound

Wikipedia contributorsAdapted for Fathomly · View authors
1 min read
Source updated February 21, 2026
Image credit is listed at the end of this article.

1ZP2MA, also known as [1-(indolizin-1-yl)propan-2-yl](methyl)amine or as 1-(indolizin-1-yl)-N-methylpropan-2-amine, is a monoamine releasing agent of the indolizinylethylamine family. It is the analogue and positional isomer of the stimulant-like drug α,N-dimethyltryptamine (α,N-DMT or N-methyl-α-methyltryptamine (N-methyl-αMT)) in which the indole ring has been replaced with an indolizine ring. 1ZP2MA has been found to be a potent dopamine releasing agent, with an EC50 of 62 nM. It is the α-methyl and N-desmethyl analogue of (2-(indolizin-1-yl)ethyl)dimethylamine (TACT908; the indolizine analogue of dimethyltryptamine (DMT)). 1ZP2MA and 2ZEDMA were patented by Tactogen in 2023.

Watch videos about 1ZP2MAExplainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “1ZP2MA”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.

Continue exploring

Related topics

Indolizinylethylamine

Indolizinylethylamines are a group of indolizine derivatives closely related to the tryptamines. They include 2ZEDMA, 1ZP2MA, and 1Z2MAP1O. Indolizinylethylamines are known to act as non-hallucinogenic serotonin receptor agonists and as monoamine releasing agents.

Substituted tryptamine

Substituted tryptamines, or simply tryptamines, also known as serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring system, joined to an amino (NH2) group via an ethyl (−CH2-CH2−) sidechain.

1Z2MAP1O

1Z2MAP1O, also known as 1--2-(methylamino)propan-1-one, is a monoamine releasing agent and serotonin receptor modulator of the indolizinylethylamine family. It is an analogue of BK-NM-AMT (β-keto-N-methyl-α-methyltryptamine) in which the indole ring has been replaced with an indolizine ring.