(R)-70
Chemical compound
(R)-70, or R-70, is a non-hallucinogenic selective serotonin 5-HT2 receptor moderate-efficacy partial agonist of the tetrahydropyridinylpyrrolopyridine family related to the psychedelic tryptamines. It shows preference for activation of the serotonin 5-HT2A receptor of about 6.4-fold relative to the serotonin 5-HT2B receptor and of about 30-fold relative to the serotonin 5-HT2C receptor. The drug is a biased agonist of the serotonin 5-HT2A receptor, activating Gq protein signaling more readily than β-arrestin2 signaling. It did not significantly produce the head-twitch response in mice, but did produce antidepressant-like effects. (R)-70, along with its close analogue (R)-69, was first described in the scientific literature by Bryan L. Roth and colleagues in 2022. It was identified via an ultra-large-scale docking campaign for the serotonin 5-HT2A receptor.
Sources and credits
This article is adapted from the Wikipedia article “(R)-70”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
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- R-70.svg by User:Innerstream, Public domain
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